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Fluoride Effect on Fertility

High doses of fluoride have repeatedly been found to interfere with the reproductive system of animals. Commonly observed effects in fluoride-exposed animals include: oxidative stress, damaged sperm, reduced sperm count, and reduced fertility.

According to the authors of a recent study in the journal Reproductive Toxicology:

"We conclude that fluoride treatment is associated with testicular disorders, which may be due to induction of oxidative stress in reproductive organs along with possible adverse effects of fluoride on pituitary testicular axis.The detailed mechanism of fluoride treatment on the male reproductive system has not been elucidated and will be the subject of future experiments " (Ghosh et al 2002).

Research on possible reproductive effects in humans is limited. Some recent research, however, indicates that fluoride exposure (at lower doses than given to animals) can cause toxic effects to human Sertoli cells and gonadotrophs, reduction in circulating testosterone, and reductions in total fertility rate. The dose at which fluoride can begin to cause these effects is not yet known.


Need for Research - Fluoride & the Reproductive System: (back to top)

“the relationship between fertility and fluoride requires additional study.”
SOURCE: National Research Council. (2006). Fluoride in Drinking Water: A Scientific Review of EPA's Standards. National Academies Press, Washington D.C.

"The effects of fluoride on the reproductive system merit further investigation in animal and human studies."
SOURCE: Department of Health & Human Services. (U.S. DHHS) (1991).
Review of Fluoride: Benefits and Risks. Department of Health and Human Services, USA. p. 88-89.

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